Age-associated cross-reactive antibody-dependent cellular cytotoxicity toward 2009 pandemic influenza A virus subtype H1N1.

  title={Age-associated cross-reactive antibody-dependent cellular cytotoxicity toward 2009 pandemic influenza A virus subtype H1N1.},
  author={Sinthujan Jegaskanda and Karen L. Laurie and Thakshila Amarasena and Wendy R. Winnall and Marit Kramski and Robert De Rose and Ian G. Barr and Andrew G. Brooks and Patrick C. Reading and Stephen J. Kent},
  journal={The Journal of infectious diseases},
  volume={208 7},
BACKGROUND During the 2009 pandemic of influenza A virus subtype H1N1 (A[H1N1]pdm09) infection, older individuals were partially protected from severe disease. It is not known whether preexisting antibodies with effector functions such as antibody-dependent cellular cytotoxicity (ADCC) contributed to the immunity observed. METHODS We tested serum specimens obtained from 182 individuals aged 1-72 years that were collected either immediately before or after the A(H1N1)pdm09 pandemic for ADCC… 

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