Age-associated cross-reactive antibody-dependent cellular cytotoxicity toward 2009 pandemic influenza A virus subtype H1N1.

@article{Jegaskanda2013AgeassociatedCA,
  title={Age-associated cross-reactive antibody-dependent cellular cytotoxicity toward 2009 pandemic influenza A virus subtype H1N1.},
  author={S. Jegaskanda and K. Laurie and T. Amarasena and W. Winnall and M. Kramski and R. De Rose and I. Barr and A. Brooks and P. Reading and S. Kent},
  journal={The Journal of infectious diseases},
  year={2013},
  volume={208 7},
  pages={
          1051-61
        }
}
BACKGROUND During the 2009 pandemic of influenza A virus subtype H1N1 (A[H1N1]pdm09) infection, older individuals were partially protected from severe disease. It is not known whether preexisting antibodies with effector functions such as antibody-dependent cellular cytotoxicity (ADCC) contributed to the immunity observed. METHODS We tested serum specimens obtained from 182 individuals aged 1-72 years that were collected either immediately before or after the A(H1N1)pdm09 pandemic for ADCC… Expand
Influenza virus A(H1N1)2009 antibody-dependent cellular cytotoxicity in young children prior to the H1N1 pandemic.
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Fc functional antibodies in humans with severe H7N9 and seasonal influenza.
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