Age-associated cross-reactive antibody-dependent cellular cytotoxicity toward 2009 pandemic influenza A virus subtype H1N1.

@article{Jegaskanda2013AgeassociatedCA,
  title={Age-associated cross-reactive antibody-dependent cellular cytotoxicity toward 2009 pandemic influenza A virus subtype H1N1.},
  author={Sinthujan Jegaskanda and Karen L. Laurie and Thakshila Amarasena and Wendy R. Winnall and Marit Kramski and Robert De Rose and Ian G. Barr and Andrew G. Brooks and Patrick C. Reading and Stephen J. Kent},
  journal={The Journal of infectious diseases},
  year={2013},
  volume={208 7},
  pages={
          1051-61
        }
}
BACKGROUND During the 2009 pandemic of influenza A virus subtype H1N1 (A[H1N1]pdm09) infection, older individuals were partially protected from severe disease. It is not known whether preexisting antibodies with effector functions such as antibody-dependent cellular cytotoxicity (ADCC) contributed to the immunity observed. METHODS We tested serum specimens obtained from 182 individuals aged 1-72 years that were collected either immediately before or after the A(H1N1)pdm09 pandemic for ADCC… 

Figures and Tables from this paper

Influenza virus A(H1N1)2009 antibody-dependent cellular cytotoxicity in young children prior to the H1N1 pandemic.

While these antibodies were not able to neutralize the A(H1N1)2009 virus, they were able to mediate antibody-dependent cellular cytotoxicity (ADCC) in vitro upon interaction with the A (H1n1) 2009 virus, suggesting that cross-reactive antibodies could contribute to immune protection in children via ADCC.

Generation and Protective Ability of Influenza Virus-Specific Antibody-Dependent Cellular Cytotoxicity in Humans Elicited by Vaccination, Natural Infection, and Experimental Challenge.

ADCC-Ab titers increased following experimental influenza virus infection in adults and after ISV administration in both children and adults.

Relationship of preexisting influenza hemagglutination inhibition, complement-dependent lytic, and antibody-dependent cellular cytotoxicity antibodies to the development of clinical illness in a prospective study of A(H1N1)pdm09 Influenza in children.

Preexisting HAI, CDL, and ADCC antibodies in young children enrolled in a prospective cohort study of dengue during the epidemic with influenza A(H1N1)pdm09 virus were evaluated to determine associations between preexisting antibodies and the occurrence of clinical or subclinical influenza virus infection.

Antibody-Dependent Cellular Cytotoxicity Responses to Seasonal Influenza Vaccination in Older Adults

Older adults commonly have pre-existing ADCC antibodies in the absence of high HAI titers to circulating influenza strains, and in older vaccinees, ADCC response mirrored HAI antibodies and was readily detectable despite high postvaccination HAi titers.

Standard Trivalent Influenza Virus Protein Vaccination Does Not Prime Antibody-Dependent Cellular Cytotoxicity in Macaques

Improved vaccination strategies are needed to induce broad-based ADCC immunity to influenza as there was a marked difference in the ability of infection compared to that of vaccination to induce cross-reactive ADCC and CTL responses.

Fc functional antibodies in humans with severe H7N9 and seasonal influenza.

It is found that the peak generation of Fc functional HA Abs preceded that of neutralizing Abs for both severe H7N9 and seasonal influenza infections and Broadly binding HA Abs with Fc-mediated functions may be a useful component of protective immunity to severe influenza infection.

Influenza Vaccination Results in Differential Hemagglutinin Stalk-Specific Fc-Mediated Functions in Individuals Living With or Without HIV

Overall, differential regulation of Fc effector HA stalk responses was showed, suggesting that HIV infection results in unique humoral immunity in response to influenza vaccination, with relevance for future strategies that aim to target the HA stalk in this population.

Functional immune response to influenza H1N1 in children and adults after live attenuated influenza virus vaccination

The results indicate that the NI assay is more sensitive to qualitative changes in serum antibodies after LAIV, and there was a considerable difference in the immune response in children and adults after vaccination.
...

References

SHOWING 1-10 OF 42 REFERENCES

Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus.

Vaccination with recent seasonal nonadjuvanted or adjuvanted influenza vaccines induced little or no cross-reactive antibody response to 2009 H1N1 in any age group.

Cross-Reactive Influenza-Specific Antibody-Dependent Cellular Cytotoxicity Antibodies in the Absence of Neutralizing Antibodies

It is concluded that there is a remarkable degree of cross-reactivity of influenza-specific ADCC Abs in seropositive humans, which could lead to improved influenza vaccines.

Cross-Reactive T Cells Are Involved in Rapid Clearance of 2009 Pandemic H1N1 Influenza Virus in Nonhuman Primates

The results suggest that cross-reactive T cell responses can mediate early clearance of an antigenically novel influenza virus in primates and may help protect humans against severe disease caused by newly emerging pandemic influenza viruses.

Protection of Mice against Lethal Challenge with 2009 H1N1 Influenza A Virus by 1918-Like and Classical Swine H1N1 Based Vaccines

The findings in mice agree with serological data showing high prevalence of 2009 H1N1 cross-reactive antibodies only in the older population, indicating that prior infection with 1918-like viruses or vaccination against the 1976 swine H 1N1 virus in the USA are likely to provide protection against the 2009 pandemic H1n1 virus.

Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus

Crystal structures of the virus envelope protein, hemagglutinin, from 2009 H1N1 and of 1918 H1 HA in complex with a neutralizing antibody that cross-reacts with both pandemic viruses reveal an epitope that is conserved in the pandemic virus, but divergent in other known H1 HAs, from the 1930s to the present.

Effect of Priming with H1N1 Influenza Viruses of Variable Antigenic Distances on Challenge with 2009 Pandemic H1N1 Virus

Changes in the HA occurred between 1947 and 1950, such that prior infection could no longer protect against 2009 pH1N1 infection, providing a mechanistic understanding of the nature of serological cross-protection observed in people over 60 years of age during the 2009 H 1N1 pandemic.

Immunity to Pre-1950 H1N1 Influenza Viruses Confers Cross-Protection against the Pandemic Swine-Origin 2009 A (H1N1) Influenza Virus

The data provide an explanation for the decreased susceptibility of the elderly to the 2009 H1N1 outbreak and demonstrate that vaccination with the pre-1950 influenza strains can cross-protect against the pandemic swine-origin 2009 H 1N1 influenza virus.

Immune response following H1N1pdm09 vaccination: differences in antibody repertoire and avidity in young adults and elderly populations stratified by age and gender.

This is the first study in humans that provides evidence for a qualitatively superior antibody response in elderly adults after H1N1pdm09 vaccination and identifies a gender difference in postvaccination antibody avidity in adults <65 years old.

Multiple infections with seasonal influenza A virus induce cross-protective immunity against A(H1N1) pandemic influenza virus in a ferret model.

Data suggest the reduced incidence and severity of infection with A(H1N1)pdm virus in the adult population during the 2009-2010 influenza season may be a result of previous exposure to seasonal influenza A viruses.

Cross-Neutralization of 1918 and 2009 Influenza Viruses: Role of Glycans in Viral Evolution and Vaccine Design

Persistent immunity to the 1918 flu or its close relatives from childhood may inhibit the unprotected spike protein of the current 2009 pandemic flu virus and, thus, its ability to infect host cells.