Age-associated changes in gene expression and developmental competence of bovine oocytes, and a possible countermeasure against age-associated events.

@article{Takeo2013AgeassociatedCI,
  title={Age-associated changes in gene expression and developmental competence of bovine oocytes, and a possible countermeasure against age-associated events.},
  author={Shun Takeo and Ryoka Kawahara-Miki and Hiroya Goto and Feng Yi Cao and Koji Kimura and Yasunori Monji and Takehito Kuwayama and Hisataka Iwata},
  journal={Molecular reproduction and development},
  year={2013},
  volume={80 7},
  pages={508-21}
}
In general, maternal age affects the quality of oocytes and embryos. The present study aimed to examine the features and age-associated gene expression profiles of bovine oocytes and embryos as well as to discover possible countermeasures against age-associated events. Comprehensive gene expression assays of germinal vesicle and metaphase II (MII)-stage oocytes and 8- to 16-cell-stage embryos were conducted using next-generation sequencing technology. The gene expression profiles of aged cows… CONTINUE READING
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