Age-associated change in mitochondrial DNA damage.

@article{Hudson1998AgeassociatedCI,
  title={Age-associated change in mitochondrial DNA damage.},
  author={Edgar K. Hudson and Barbara A. Hogue and N C Souza-Pinto and Deborah L. Croteau and R. Michael Anson and Vilhelm A. Bohr and Richard G. Hansford},
  journal={Free radical research},
  year={1998},
  volume={29 6},
  pages={
          573-9
        }
}
  • Edgar K. Hudson, Barbara A. Hogue, +4 authors Richard G. Hansford
  • Published in Free radical research 1998
  • Chemistry, Medicine
  • There is an age-associated decline in the mitochondrial function of the Wistar rat heart. Previous reports from this lab have shown a decrease in mitochondrial cytochrome c oxidase (COX) activity associated with a reduction in COX gene and protein expression and a similar decrease in the rate of mitochondrial protein synthesis. Damage to mitochondrial DNA may contribute to this decline. Using the HPLC-Coularray system (ESA, USA), we measured levels of nuclear and mitochondrial 8-oxo-2… CONTINUE READING

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