Age-associated alterations in calcium current and its modulation in cardiac myocytes.

Abstract

The calcium current is one of the most important components in cardiac excitation-contraction coupling. During aging, the magnitude of L-type Ca++ channel current (ICa,L) is significantly increased in parallel with the enlargement of cardiac myocytes, resulting in unaltered ICa,L density. Since the inactivation of ICa,L is slowed and the action potential… (More)

Topics

Cite this paper

@article{Zhou1998AgeassociatedAI, title={Age-associated alterations in calcium current and its modulation in cardiac myocytes.}, author={Y. Y. Zhou and E. G. Lakatta and Ruoyu Xiao}, journal={Drugs & aging}, year={1998}, volume={13 2}, pages={159-71} }