Age-associated alteration of gene expression patterns in mouse oocytes.

  title={Age-associated alteration of gene expression patterns in mouse oocytes.},
  author={Toshio Hamatani and Geppino Falco and Mark G. Carter and Hidenori Akutsu and Carole Stagg and Alexei A. Sharov and Dawood Babu Dudekula and Vincent VanBuren and Minoru S. H. Ko},
  journal={Human molecular genetics},
  volume={13 19},
Decreasing oocyte competence with maternal aging is a major factor in human infertility. To investigate the age-dependent molecular changes in a mouse model, we compared the expression profiles of metaphase II oocytes collected from 5- to 6-week-old mice with those collected from 42- to 45-week-old mice using the NIA 22K 60-mer oligo microarray. Among approximately 11,000 genes whose transcripts were detected in oocytes, about 5% (530) showed statistically significant expression changes… 

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