Age-associated alteration of gene expression patterns in mouse oocytes.

@article{Hamatani2004AgeassociatedAO,
  title={Age-associated alteration of gene expression patterns in mouse oocytes.},
  author={T. Hamatani and G. Falco and M. G. Carter and H. Akutsu and C. Stagg and A. Sharov and Dawood B. Dudekula and V. VanBuren and M. Ko},
  journal={Human molecular genetics},
  year={2004},
  volume={13 19},
  pages={
          2263-78
        }
}
Decreasing oocyte competence with maternal aging is a major factor in human infertility. To investigate the age-dependent molecular changes in a mouse model, we compared the expression profiles of metaphase II oocytes collected from 5- to 6-week-old mice with those collected from 42- to 45-week-old mice using the NIA 22K 60-mer oligo microarray. Among approximately 11,000 genes whose transcripts were detected in oocytes, about 5% (530) showed statistically significant expression changes… Expand
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