• Biology, Medicine
  • Published in Genetics 2003

Age-associated activation of epigenetically repressed genes in the mouse.

@article{BennettBaker2003AgeassociatedAO,
  title={Age-associated activation of epigenetically repressed genes in the mouse.},
  author={P E Bennett-Baker and Jodi M. Wilkowski and David T Burke},
  journal={Genetics},
  year={2003},
  volume={165 4},
  pages={
          2055-62
        }
}
Epigenetic control of gene expression is a consistent feature of differentiated mammalian cell types. Epigenetic expression patterns are mitotically heritable and are stably maintained in adult cells. However, unlike somatic DNA mutation, little is known about the occurrence of epigenetic change, or epimutation, during normal adult life. We have monitored the age-associated maintenance of two epigenetic systems--X inactivation and genomic imprinting--using the genes Atp7a and Igf2, respectively… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 10 REFERENCES

Feinberg , regulation at the nanomolar scale

I. L. Horon, R. Ohlsson, S. R. Hamilton, P. A.
  • Trends Genet .
  • 1999

Molecular biology of aging

P. A. Jones
  • 1999

Use of transgenic mouse models for studying somatic

B. M. Cattanach
  • 1995

An investigation of mutation as a function of age in humans

K. E. Latham
  • Mutat . Res .
  • 1994

A sensitive , patients with microsatellite instability

J. M. LeBon, A. D. Riggs
  • Nat . Med .
  • 1992

Dysdifferentiative hypothesis of aging : a review , differing by a single nucleotide

R. G. Cutler
  • PCR Methods Appl .
  • 1985
VIEW 1 EXCERPT

On the nature of the aging process

E. M. Eicher
  • Proc . Natl . Expression Acad . Sci . USA
  • 1959