Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1).

@article{Ouyang2003AgeassociatedAO,
  title={Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1).},
  author={Qin Ouyang and Wolfgang Wagner and David Voehringer and Anders Wikby and Tatjana Klatt and Steffen Walter and Claudia Anna M{\"u}ller and Hanspeter Pircher and Graham P Pawelec},
  journal={Experimental gerontology},
  year={2003},
  volume={38 8},
  pages={911-20}
}
Large clonal expansions of peripheral CD8+ T cells carrying receptors for single epitopes of CMV and EBV are common in the elderly and may be associated with an immune risk phenotype predicting mortality. Here we show that the frequency of CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1), a marker of cells unable to undergo further clonal expansion, was markedly elevated in CD8+ T cells from old donors. Moreover, tetramer staining revealed that the elevated… CONTINUE READING