Age-associated DNA methylation in pediatric populations.

@article{Alisch2012AgeassociatedDM,
  title={Age-associated DNA methylation in pediatric populations.},
  author={Reid S Alisch and Benjamin G Barwick and Pankaj Chopra and Leila K Myrick and Glen A. Satten and Karen N. Conneely and Stephen T Warren},
  journal={Genome research},
  year={2012},
  volume={22 4},
  pages={623-32}
}
DNA methylation (DNAm) plays diverse roles in human biology, but this dynamic epigenetic mark remains far from fully characterized. Although earlier studies uncovered loci that undergo age-associated DNAm changes in adults, little is known about such changes during childhood. Despite profound DNAm plasticity during embryogenesis, monozygotic twins show indistinguishable childhood methylation, suggesting that DNAm is highly coordinated throughout early development. Here we examine the… CONTINUE READING
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