Age-associated DNA methylation in pediatric populations.

  title={Age-associated DNA methylation in pediatric populations.},
  author={Reid S Alisch and Benjamin G Barwick and Pankaj Chopra and Leila K Myrick and Glen A. Satten and Karen N. Conneely and Stephen T Warren},
  journal={Genome research},
  volume={22 4},
DNA methylation (DNAm) plays diverse roles in human biology, but this dynamic epigenetic mark remains far from fully characterized. Although earlier studies uncovered loci that undergo age-associated DNAm changes in adults, little is known about such changes during childhood. Despite profound DNAm plasticity during embryogenesis, monozygotic twins show indistinguishable childhood methylation, suggesting that DNAm is highly coordinated throughout early development. Here we examine the… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 115 extracted citations

DNA Methylation in Whole Blood: Uses and Challenges

Current Environmental Health Reports • 2015
View 5 Excerpts
Highly Influenced

Reconfiguration of DNA methylation in aging

Mechanisms of Ageing and Development • 2015
View 4 Excerpts
Highly Influenced

econfiguration of DNA methylation in aging

ichele Zampieri, Fabio Ciccaronea, +3 authors Paola Caiafaa
View 4 Excerpts
Highly Influenced

Epigenomic Indicators of Age in African Americans

Hereditary genetics : current research • 2014
View 8 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 47 references

Similar Papers

Loading similar papers…