Age- and sodium-sensitive hypertension and sex-dependent renal changes in rats with a reduced nephron number.

@article{Salazar2008AgeAS,
  title={Age- and sodium-sensitive hypertension and sex-dependent renal changes in rats with a reduced nephron number.},
  author={Francisco J. Salazar and Virginia Reverte and Fara Saez and Anal{\'i}a Loria and Maria Teresa Llin{\'a}s},
  journal={Hypertension},
  year={2008},
  volume={51 4},
  pages={1184-9}
}
We have demonstrated that the reduction of angiotensin II effects during the nephrogenic period reduces the nephron number and induces the development of hypertension. The hypotheses examined are that this reduction of angiotensin effects leads to the development of an age-dependent sodium sensitive hypertension and that the hypertension is angiotensin II dependent. Newborn rats were treated with an angiotensin II type 1 receptor antagonist during the first 2 weeks of age. At 3 to 4 and 11 to… CONTINUE READING