Age and sex dependent genetic effects of neuropeptide Y promoter polymorphism on susceptibility to ischemic stroke in Koreans.

@article{Kim2010AgeAS,
  title={Age and sex dependent genetic effects of neuropeptide Y promoter polymorphism on susceptibility to ischemic stroke in Koreans.},
  author={No Soo Kim and Mi Mi Ko and Min Ho Cha and Se-mi Oh and Ok Bang},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2010},
  volume={411 17-18},
  pages={1243-7}
}
BACKGROUND In our previous study, the neuropeptide Y (NPY) C-399T promoter polymorphism (rs16147C>T) was identified as a risk factor for ischemic stroke in Koreans. In this study, we investigated whether age and sex modify the genetic effect of C-399T on susceptibility to ischemic stroke. METHODS A total of 1,350 subjects (802 ischemic stroke patients, 548 healthy controls) were genotyped for C-399T using a primer extension method. The results were statistically analyzed for the genetic… CONTINUE READING