Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes.

@article{Clee2000AgeAR,
  title={Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes.},
  author={Susanne M Clee and John J. P. Kastelein and M Nicole van Dam and Michel Marcil and Kirsten Roomp and Karin Y. Zwarts and Jennifer A. Collins and Roosje Roelants and Naoki Tamasawa and Tom{\'a}{\vs} {\vS}tulc and Toshihiro Suda and Richard {\vC}e{\vs}ka and Betsie Boucher and Claude Rondeau and C DeSouich and Angie Brooks-Wilson and Henri O.F. Molhuizen and Jiri Frohlich and Jacques J Genest and Michael R. Hayden},
  journal={The Journal of clinical investigation},
  year={2000},
  volume={106 10},
  pages={1263-70}
}
We and others have recently identified mutations in the ABCA1 gene as the underlying cause of Tangier disease (TD) and of a dominantly inherited form of familial hypoalphalipoproteinemia (FHA) associated with reduced cholesterol efflux. We have now identified 13 ABCA1 mutations in 11 families (five TD, six FHA) and have examined the phenotypes of 77 individuals heterozygous for mutations in the ABCA1 gene. ABCA1 heterozygotes have decreased HDL cholesterol (HDL-C) and increased triglycerides… CONTINUE READING