Age and origin of two common MLH1 mutations predisposing to hereditary colon cancer.

@article{Moisio1996AgeAO,
  title={Age and origin of two common MLH1 mutations predisposing to hereditary colon cancer.},
  author={A L Moisio and Pertti Sistonen and Jean Weissenbach and Albert de la Chapelle and P{\"a}ivi Peltom{\"a}ki},
  journal={American journal of human genetics},
  year={1996},
  volume={59 6},
  pages={
          1243-51
        }
}
Two mutations in the DNA mismatch repair gene MLH1, referred to as mutations 1 and 2, are frequent among Finnish kindreds with hereditary nonpolyposis colorectal cancer (HNPCC). In order to assess the ages and origins of these mutations, we constructed a map of 15 microsatellite markers around MLH1 and used this information in haplotype analyses of 19 kindreds with mutation 1 and 6 kindreds with mutation 2. All kindreds with mutation 1 showed a single allele for the intragenic marker D3S1611… CONTINUE READING
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