Age and insulin-like growth factor-1 modulate N-methyl-D-aspartate receptor subtype expression in rats

@article{Sonntag2000AgeAI,
  title={Age and insulin-like growth factor-1 modulate N-methyl-D-aspartate receptor subtype expression in rats},
  author={William Edmund Sonntag and Sean A. Bennett and Amir Showkat Khan and Phillip L. Thornton and Judy Karen Brunso-Bechtold},
  journal={Brain Research Bulletin},
  year={2000},
  volume={51},
  pages={331-338}
}
N-Methyl-D-aspartate (NMDA) receptors have been reported to have an important role in synaptic plasticity and neurodegeneration. Two major subtypes of these receptors, NMDAR1 and NMDAR2, are present in brain and heterogeneity of these receptors have been reported to define specific functional responses. In this study, the effects of age and chronic insulin-like growth factor-1 (IGF-1) administration on NMDA receptor density and subtype expression were investigated in frontal cortex, CA1, CA2/3… CONTINUE READING

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