Age and hypertrophy related changes in contractile post-rest behavior and action potential properties in isolated rat myocytes

@article{WeisserThomas2007AgeAH,
  title={Age and hypertrophy related changes in contractile post-rest behavior and action potential properties in isolated rat myocytes},
  author={Jutta Weisser-Thomas and Quan Nguyen and Manuela Schuettel and Daniel E. Thomas and U. Dreiner and Christian Groh{\'e} and Rainer Meyer},
  journal={AGE},
  year={2007},
  volume={29},
  pages={205-217}
}
“Physiological” aging as well as early and progressive cardiac hypertrophy may affect action potential (AP) pattern, contractile function, and Ca2+ handling. We hypothesize that contractile function is disturbed in hypertrophy from early stages and is differently affected in aged myocardium. In vivo function, cardiomyocyte contractile behavior and APs were compared in Wistar-Kyoto (WIS) rats and spontaneously hypertensive rats (SHR) at different ages and degrees of hypertrophy (3–4, 9–11, 20–24… CONTINUE READING
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