Age and gender influence basal and stress-modulated hypothalamic-pituitary-thyroidal function in Fischer 344/N rats.

@article{Cizza1996AgeAG,
  title={Age and gender influence basal and stress-modulated hypothalamic-pituitary-thyroidal function in Fischer 344/N rats.},
  author={Giovanni Cizza and Linda Brady and M E Esclapes and Marc R. Blackman and Philip W. Gold and George P. Chrousos},
  journal={Neuroendocrinology},
  year={1996},
  volume={64 6},
  pages={440-8}
}
To investigate possible gender- and age-associated changes of the hypothalamic-pituitary-thyroid (HPT) axis at baseline and during stress, we studied healthy young (3-month) and old (23-month) female 344/N Fischer rats at the basal state and after 2 h of immobilization (IMMO), in parallel to age-matched male rats. At baseline, there were no major differences on HPT axis functions between young female and male animals. Old age was associated with impaired central thyroid function in both genders… CONTINUE READING

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