Age and gender effects on ondansetron pharmacokinetics: evaluation of healthy aged volunteers.

@article{Pritchard1992AgeAG,
  title={Age and gender effects on ondansetron pharmacokinetics: evaluation of healthy aged volunteers.},
  author={J. Frederick Pritchard and J S Bryson and A E Kernodle and Thomas Benedetti and J. Robert Powell},
  journal={Clinical pharmacology and therapeutics},
  year={1992},
  volume={51 1},
  pages={51-5}
}
Modest differences in the clearance of the 5HT3 antagonist, ondansetron, among different age groups were detected in two groups of healthy elderly volunteers, one group aged 61 to 74 years ("elderly") and the other 75 to 82 ("aged") years, in addition to young healthy subjects. Both a single 0.15 mg/kg intravenous dose and a single 8 mg oral dose were administered according to a randomized crossover design with a minimum 3-day washout period between treatments. Mean plasma clearance decreased… CONTINUE READING

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