Age and gender effects on chlordiazepoxide kinetics: relation to antipyrine disposition.

@article{Greenblatt1989AgeAG,
  title={Age and gender effects on chlordiazepoxide kinetics: relation to antipyrine disposition.},
  author={David J Greenblatt and Marcia Divoll and Darrell R. Abernethy and Hermann Rudolf Ochs and Jerold S. Harmatz and Richard I. Shader},
  journal={Pharmacology},
  year={1989},
  volume={38 5},
  pages={327-34}
}
Twelve normal subjects aged 24-41 years, and 12 subjects aged 62-79 years, received single 50-mg doses of chlordiazepoxide hydrochloride by mouth and by intravenous injection on two occasions. Chlordiazepoxide volume of distribution was significantly correlated with body weight (r = 0.63, p less than 0.001), but was not related to age or sex. Among male subjects, elimination half-life was prolonged (20 vs. 8 h, p less than 0.025) and clearance reduced (20 vs. 43 ml/min, p less than 0.05) in… CONTINUE READING