Age- and disease-related changes of calcium channel-mediated currents in human Müller glial cells.

  title={Age- and disease-related changes of calcium channel-mediated currents in human M{\"u}ller glial cells.},
  author={Andreas Bringmann and Bernd Biedermann and Ute Schnurbusch and Volker Enzmann and Frank Faude and Andreas Reichenbach},
  journal={Investigative ophthalmology & visual science},
  volume={41 9},
PURPOSE To determine whether the expression of voltage-gated Ca2+ channels in human Müller glial cells changes during normal aging and in cells from patients with proliferative vitreoretinopathy (PVR). METHODS Müller cells were enzymatically isolated from retinas of healthy donors and from excised retinal pieces of patients with PVR, and the whole-cell, voltage-clamp technique was used to characterize the current densities of transient, low-voltage-activated calcium channels and of sustained… CONTINUE READING


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Müller glial cells in retinal disease.

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