Age and acute myeloid leukemia.

  title={Age and acute myeloid leukemia.},
  author={Frederick R Appelbaum and Holly M Gundacker and David R. Head and Marilyn L. Slovak and Cheryl L. Willman and John E. Godwin and Jeanne E. Anderson and Stephen H. Petersdorf},
  volume={107 9},
We conducted a retrospective analysis of 968 adults with acute myeloid leukemia (AML) on 5 recent Southwest Oncology Group trials to understand how the nature of AML changes with age. Older study patients with AML presented with poorer performance status, lower white blood cell counts, and a lower percentage of marrow blasts. Multidrug resistance was found in 33% of AMLs in patients younger than age 56 compared with 57% in patients older than 75. The percentage of patients with favorable… CONTINUE READING
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