Age-acquired immunity to a Plasmodium vivax invasion ligand, the duffy binding protein.

@article{ColeTobian2002AgeacquiredIT,
  title={Age-acquired immunity to a Plasmodium vivax invasion ligand, the duffy binding protein.},
  author={Jennifer L Cole-Tobian and Alfred Cort{\'e}s and Moses Baisor and Will Kastens and Jia Xainli and Moses John Bockarie and John H Adams and Christopher L King},
  journal={The Journal of infectious diseases},
  year={2002},
  volume={186 4},
  pages={531-9}
}
The interaction between the Plasmodium vivax merozoite Duffy binding protein region II (DBPII) and the human erythrocyte Duffy antigen leads to infection. Highly polymorphic regions of this protein may have arisen as a mechanism to avoid host immunity. To examine whether immunity to P. vivax is directed against these polymorphic regions of DBPII, age-associated changes in the frequency of specific DBPII alleles among 358 P. vivax-positive Papua New Guineans were examined. Although the overall… CONTINUE READING

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The neglected burden of Plasmodium vivax malaria.

The American journal of tropical medicine and hygiene • 2001
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