Age-Related Retinopathy in NRF2-Deficient Mice

Abstract

BACKGROUND Cumulative oxidative damage is implicated in the pathogenesis of age-related macular degeneration (AMD). Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that plays key roles in retinal antioxidant and detoxification responses. The purposes of this study were to determine whether NRF2-deficient mice would develop AMD… (More)
DOI: 10.1371/journal.pone.0019456

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@inproceedings{Zhao2011AgeRelatedRI, title={Age-Related Retinopathy in NRF2-Deficient Mice}, author={Zhenyang Zhao and Yan Chen and Jian Wang and P. Sternberg and Michael L. Freeman and Hans E. Grossniklaus and Jiyang Cai}, booktitle={PloS one}, year={2011} }