Age-Related Memory Impairment Is Associated with Disrupted Multivariate Epigenetic Coordination in the Hippocampus

@article{Castellano2012AgeRelatedMI,
  title={Age-Related Memory Impairment Is Associated with Disrupted Multivariate Epigenetic Coordination in the Hippocampus},
  author={James F. Castellano and B. Fletcher and B. Kelley-Bell and D. Kim and M. Gallagher and P. Rapp},
  journal={PLoS ONE},
  year={2012},
  volume={7}
}
  • James F. Castellano, B. Fletcher, +3 authors P. Rapp
  • Published 2012
  • Biology, Medicine
  • PLoS ONE
  • Mounting evidence linking epigenetic regulation to memory-related synaptic plasticity raises the possibility that altered chromatin modification dynamics might contribute to age-dependent cognitive decline. Here we show that the coordinated orchestration of both baseline and experience-dependent epigenetic regulation seen in the young adult hippocampus is lost in association with cognitive aging. Using a well-characterized rat model that reliably distinguishes aged individuals with significant… CONTINUE READING
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