• Medicine, Biology
• Published in PloS one 2012
• DOI:10.1371/journal.pone.0033249

Age-Related Memory Impairment Is Associated with Disrupted Multivariate Epigenetic Coordination in the Hippocampus

@inproceedings{Castellano2012AgeRelatedMI,
  title={Age-Related Memory Impairment Is Associated with Disrupted Multivariate Epigenetic Coordination in the Hippocampus},
  author={James F. Castellano and Bonnie R. Fletcher and Bennett Kelley-Bell and David H. Kim and Michela Gallagher and Peter R Rapp},
  booktitle={PloS one},
  year={2012}
}

• James F. Castellano, Bonnie R. Fletcher, +3 authors Peter R Rapp

Mounting evidence linking epigenetic regulation to memory-related synaptic plasticity raises the possibility that altered chromatin modification dynamics might contribute to age-dependent cognitive decline. Here we show that the coordinated orchestration of both baseline and experience-dependent epigenetic regulation seen in the young adult hippocampus is lost in association with cognitive aging. Using a well-characterized rat model that reliably distinguishes aged individuals with significant… CONTINUE READING

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