Age-Related Memory Impairment Is Associated with Disrupted Multivariate Epigenetic Coordination in the Hippocampus

@inproceedings{Castellano2012AgeRelatedMI,
  title={Age-Related Memory Impairment Is Associated with Disrupted Multivariate Epigenetic Coordination in the Hippocampus},
  author={James F. Castellano and Bonnie R. Fletcher and Bennett Kelley-Bell and David H. Kim and Michela Gallagher and Peter R Rapp},
  booktitle={PloS one},
  year={2012}
}
Mounting evidence linking epigenetic regulation to memory-related synaptic plasticity raises the possibility that altered chromatin modification dynamics might contribute to age-dependent cognitive decline. Here we show that the coordinated orchestration of both baseline and experience-dependent epigenetic regulation seen in the young adult hippocampus is lost in association with cognitive aging. Using a well-characterized rat model that reliably distinguishes aged individuals with significant… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 31 CITATIONS

Experience Modulates the Effects of Histone Deacetylase Inhibitors on Gene and Protein Expression in the Hippocampus: Impaired Plasticity in Aging.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2015
VIEW 12 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS

HDAC inhibition facilitates the switch between memory systems in young but not aged mice.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2013
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Aging in the Brain: New Roles of Epigenetics in Cognitive Decline

  • The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2018

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES