Age-Related Memory Impairment Is Associated with Disrupted Multivariate Epigenetic Coordination in the Hippocampus

  title={Age-Related Memory Impairment Is Associated with Disrupted Multivariate Epigenetic Coordination in the Hippocampus},
  author={James F. Castellano and B. Fletcher and B. Kelley-Bell and D. Kim and M. Gallagher and P. Rapp},
  journal={PLoS ONE},
  • James F. Castellano, B. Fletcher, +3 authors P. Rapp
  • Published 2012
  • Biology, Medicine
  • PLoS ONE
  • Mounting evidence linking epigenetic regulation to memory-related synaptic plasticity raises the possibility that altered chromatin modification dynamics might contribute to age-dependent cognitive decline. Here we show that the coordinated orchestration of both baseline and experience-dependent epigenetic regulation seen in the young adult hippocampus is lost in association with cognitive aging. Using a well-characterized rat model that reliably distinguishes aged individuals with significant… CONTINUE READING
    59 Citations

    Figures, Tables, and Topics from this paper

    Epigenetic contributions to cognitive aging: disentangling mindspan and lifespan.
    • 30
    • PDF
    Epigenetic mechanisms related to cognitive decline during aging
    • 16
    • Highly Influenced
    Epigenetic Mechanisms of Learning and Memory: Implications for Aging
    • Highly Influenced
    • PDF
    Survey of the Arc Epigenetic Landscape in Normal Cognitive Aging
    • 2
    Age‐related changes in Egr1 transcription and DNA methylation within the hippocampus
    • 40
    • Highly Influenced
    Epigenetic regulation of memory: implications in human cognitive disorders
    • J. Kramer
    • Biology, Medicine
    • Biomolecular concepts
    • 2013
    • 16
    • PDF
    CREB-binding protein levels in the rat hippocampus fail to predict chronological or cognitive aging
    • 12
    Reassessing the effects of histone deacetylase inhibitors on hippocampal memory and cognitive aging
    • 24


    Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice
    • 757
    • Highly Influential
    • PDF
    Prominent hippocampal CA3 gene expression profile in neurocognitive aging
    • 70
    • PDF
    Recovery of learning and memory is associated with chromatin remodelling
    • 1,014
    Epigenetic mechanisms underlying extinction of memory and drug-seeking behavior
    • 24
    Age-related changes in Arc transcription and DNA methylation within the hippocampus
    • 182
    Epigenetic Mechanisms in Cognition
    • 391
    Preserved neuron number in the hippocampus of aged rats with spatial learning deficits.
    • P. Rapp, M. Gallagher
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1996
    • 620
    • PDF
    Age-related spatial learning impairment is unrelated to spinophilin immunoreactive spine number and protein levels in rat hippocampus
    • 18
    Circuit-Specific Alterations in Hippocampal Synaptophysin Immunoreactivity Predict Spatial Learning Impairment in Aged Rats
    • 364
    • PDF
    HDAC2 negatively regulates memory formation and synaptic plasticity
    • 1,245
    • Highly Influential
    • PDF