Age-Related Memory Impairment Is Associated with Disrupted Multivariate Epigenetic Coordination in the Hippocampus
@article{Castellano2012AgeRelatedMI, title={Age-Related Memory Impairment Is Associated with Disrupted Multivariate Epigenetic Coordination in the Hippocampus}, author={James F. Castellano and B. Fletcher and B. Kelley-Bell and D. Kim and M. Gallagher and P. Rapp}, journal={PLoS ONE}, year={2012}, volume={7} }
Mounting evidence linking epigenetic regulation to memory-related synaptic plasticity raises the possibility that altered chromatin modification dynamics might contribute to age-dependent cognitive decline. Here we show that the coordinated orchestration of both baseline and experience-dependent epigenetic regulation seen in the young adult hippocampus is lost in association with cognitive aging. Using a well-characterized rat model that reliably distinguishes aged individuals with significant… CONTINUE READING
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References
SHOWING 1-10 OF 45 REFERENCES
Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice
- Biology, Medicine
- Science
- 2010
- 757
- Highly Influential
- PDF
Prominent hippocampal CA3 gene expression profile in neurocognitive aging
- Psychology, Medicine
- Neurobiology of Aging
- 2011
- 70
- PDF
Recovery of learning and memory is associated with chromatin remodelling
- Biology, Medicine
- Nature
- 2007
- 1,014
Epigenetic mechanisms underlying extinction of memory and drug-seeking behavior
- Biology, Medicine
- Mammalian Genome
- 2009
- 24
Age-related changes in Arc transcription and DNA methylation within the hippocampus
- Biology, Medicine
- Neurobiology of Aging
- 2011
- 182
Preserved neuron number in the hippocampus of aged rats with spatial learning deficits.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1996
- 620
- PDF
Age-related spatial learning impairment is unrelated to spinophilin immunoreactive spine number and protein levels in rat hippocampus
- Psychology, Medicine
- Neurobiology of Aging
- 2008
- 18
Circuit-Specific Alterations in Hippocampal Synaptophysin Immunoreactivity Predict Spatial Learning Impairment in Aged Rats
- Psychology, Medicine
- The Journal of Neuroscience
- 2000
- 364
- PDF
HDAC2 negatively regulates memory formation and synaptic plasticity
- Biology, Medicine
- Nature
- 2009
- 1,245
- Highly Influential
- PDF