Age-Related Hearing Impairment (ARHI) Associated with GJB2 Single Mutation IVS1+1G>A in the Yakut Population Isolate in Eastern Siberia

@inproceedings{Barashkov2014AgeRelatedHI,
  title={Age-Related Hearing Impairment (ARHI) Associated with GJB2 Single Mutation IVS1+1G>A in the Yakut Population Isolate in Eastern Siberia},
  author={Nikolay A Barashkov and Fedor M Teryutin and Vera G Pshennikova and Aisen V. Solovyev and Leonid A. Klarov and Natalya A. Solovyeva and Andrei A. Kozhevnikov and Lena M. Vasilyeva and Elvira E. Fedotova and Maria V. Pak and Sargylana N. Lekhanova and Elena V. Zakharova and Kyunney E. Savvinova and Nyurgun N Gotovtsev and Adyum M. Rafailo and Nikolay V. Luginov and Anatoliy N. Alexeev and Olga L Posukh and Lilya U. Dzhemileva and Elza Khusnutdinova and Sardana A. Fedorova},
  booktitle={PloS one},
  year={2014}
}
Age-Related Hearing Impairment (ARHI) is one of the frequent sensory disorders registered in 50% of individuals over 80 years. ARHI is a multifactorial disorder due to environmental and poor-known genetic components. In this study, we present the data on age-related hearing impairment of 48 heterozygous carriers of mutation IVS1+1G>A (GJB2 gene) and 97 subjects with GJB2 genotype wt/wt in the Republic of Sakha/Yakutia (Eastern Siberia, Russia). This subarctic territory was found as the region… CONTINUE READING
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