Age-Related Decline in Brain Resources Modulates Genetic Effects on Cognitive Functioning

@article{Lindenberger2008AgeRelatedDI,
  title={Age-Related Decline in Brain Resources Modulates Genetic Effects on Cognitive Functioning},
  author={Ulman Lindenberger and Irene E. Nagel and Christian Chicherio and Shu-Chen Li and Hauke R. Heekeren and Lars B{\"a}ckman},
  journal={Frontiers in Neuroscience},
  year={2008},
  volume={2},
  pages={234 - 244}
}
Individual differences in cognitive performance increase from early to late adulthood, likely reflecting influences of a multitude of factors. We hypothesize that losses in neurochemical and anatomical brain resources in normal aging modulate the effects of common genetic variations on cognitive functioning. Our hypothesis is based on the assumption that the function relating brain resources to cognition is nonlinear, so that genetic differences exert increasingly large effects on cognition as… 

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