Age-Related Changes in Noradrenergic Sympathetic Innervation of the Rat Spleen Is Strain Dependent

@article{Bellinger2002AgeRelatedCI,
  title={Age-Related Changes in Noradrenergic Sympathetic Innervation of the Rat Spleen Is Strain Dependent},
  author={D. Bellinger and Lily Tran and Joey I. Kang and C. Lubahn and D. Felten and D. Lorton},
  journal={Brain, Behavior, and Immunity},
  year={2002},
  volume={16},
  pages={247-261}
}
Previous findings from our laboratory revealed an age-related decline in noradrenergic (NA) sympathetic innervation of the spleen in male Fischer 344 (F344) rats. The purpose of this study was to determine whether other rat strains also progressively lose NA sympathetic nerves in the aging spleen. Sympathetic innervation of spleens from 3- and 21-month-old male F344, Brown Norway (BN), BN X F344 (BNF(1)), and Lewis rats was examined using fluorescence histochemistry to localize catecholamines… Expand
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References

SHOWING 1-10 OF 41 REFERENCES
A longitudinal study of age-related loss of noradrenergic nerves and lymphoid cells in the rat spleen
TLDR
The age-related decline in NA innervation of spleen and in the density of specific populations of cells of the immune system (T lymphocytes and antigen-presenting ED3+ macrophages), that follow remarkably similar time courses, supports functional evidence for dynamic interactions between theimmune system and NA sympathetic nerves in the spleen. Expand
Maintenance of noradrenergic sympathetic innervation in the involuted thymus of the aged Fischer 344 rat
TLDR
The findings suggest that the thymus is able to maintain NA innervation in the face of involution, and that these fibers provide a NA-enriched microenvironment for interaction with adrenergic receptors on thymocytes. Expand
Noradrenergic sympathetic innervation of the spleen: IV. Morphometric analysis in adult and aged F344 rats
TLDR
It is proposed that a causal relationship may exist between diminished innervation and diminished immune function in aged rats and that chemical sympathectomy of the spleen is followed by an 80% reduction in primary antibody responses to a T‐dependent antigen challenge. Expand
Alterations in sympathetic innervation of thymus and spleen in aged mice
TLDR
The alterations in sympathetic NA innervation of lymphoid organs with age suggest that the sympathetic nervous system and NE may play a role in age-associated immune dysregulation. Expand
Alterations in T lymphocyte activity following chemical sympathectomy in young and old Fischer 344 rats
TLDR
The sympathectomy-induced reduction in T cell proliferation indicates that splenic NA innervation in old animals, though diminished, can exert a positive regulatory influence on T lymphocyte function. Expand
Effect of age, gender, rat strain, and dietary restriction, on norepinephrine release from cardiac synaptosomes.
TLDR
It is demonstrated that aging reduces the capacity of cardiac adrenergic nerve terminals to release NE, this age-related change is not strain specific, and that dietary restriction and gender alter the extent of this change with age. Expand
Decreased sympathetic innervation of spleen in aged fischer 344 rats
TLDR
The relationship between diminished noradrenergic innervation and diminished immune responsiveness in aging mammals, while not clear on a causal level, is presented as a hypothesis for further testing. Expand
Effect of aging on rat skeletal muscle beta-AR function in male Fischer 344 x brown Norway rats.
TLDR
There was an age-associated increase in pNE concentrations in male F344xBN rats, suggesting an increase in sympathetic nervous system activity, whereas in skeletal muscle beta-AR-stimulated AC activity remained unchanged with age. Expand
Ontogeny and Senescence of Noradrenergic Innervation of the Rodent Thymus and Spleen
TLDR
This chapter explores the ontogeny, maturation, and senescence of noradrenergic (NA) sympathetic neurotransmission in two lymphoid organs and presents a study in which NA innervation was maintained in some aged rodents and increased in density in the thymus as a result of thymic involution. Expand
Innervation of lymphoid organs and implications in development, aging, and autoimmunity.
TLDR
This chapter describes noradrenergic and peptidergic innervation of primary and secondary lymphoid organs in development, at maturation and during the normal aging process, and discusses possible functional implications of direct neural signals onto cells of the immune system at critical time points in the lifespan of an animal. Expand
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