Age-Related Changes in Noradrenergic Sympathetic Innervation of the Rat Spleen Is Strain Dependent

  title={Age-Related Changes in Noradrenergic Sympathetic Innervation of the Rat Spleen Is Strain Dependent},
  author={Denise Lorton Bellinger and Lily Tran and Joey I. Kang and Cheri L. Lubahn and David L. Felten and Dianne Lorton},
  journal={Brain, Behavior, and Immunity},
Previous findings from our laboratory revealed an age-related decline in noradrenergic (NA) sympathetic innervation of the spleen in male Fischer 344 (F344) rats. The purpose of this study was to determine whether other rat strains also progressively lose NA sympathetic nerves in the aging spleen. Sympathetic innervation of spleens from 3- and 21-month-old male F344, Brown Norway (BN), BN X F344 (BNF(1)), and Lewis rats was examined using fluorescence histochemistry to localize catecholamines… 

Sympathetic innervation of the spleen in male Brown Norway rats: A longitudinal aging study

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