Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in Drosophila.

Insulin and insulin-growth-factor-like signaling (IIS) plays important roles in the regulation of development, growth, metabolic homeostasis, and aging, as well as in brain functions such as learning and memory. The temporal-spatial role of IIS in learning and memory and its effect on age-dependent memory impairment remain unclear. Here, we report that… CONTINUE READING