Age-Related Changes in Human Peripheral Blood IGH Repertoire Following Vaccination

  title={Age-Related Changes in Human Peripheral Blood IGH Repertoire Following Vaccination},
  author={Yu-Chang Bryan Wu and David Kipling and Deborah Dunn-Walters},
  booktitle={Front. Immun.},
Immune protection against pulmonary infections, such as seasonal flu and invasive pneumonia, is severely attenuated with age, and vaccination regimes for the elderly people often fail to elicit effective immune response. We have previously shown that influenza and pneumococcal vaccine responses in the older population are significantly impaired in terms of serum antibody production, and have shown repertoire differences by CDR-H3 spectratype analysis. Here we report a detailed analysis of the B… CONTINUE READING
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