Age-Related Cellular Copper Dynamics in the Fungal Ageing Model Podospora anserina and in Ageing Human Fibroblasts

  title={Age-Related Cellular Copper Dynamics in the Fungal Ageing Model Podospora anserina and in Ageing Human Fibroblasts},
  author={C. Scheckhuber and J. Grief and Emmanuelle Boilan and Karin Luce and F. Debacq-Chainiaux and C. Rittmeyer and R. Gredilla and B. Kolbesen and O. Toussaint and H. Osiewacz},
  journal={PLoS ONE},
  • C. Scheckhuber, J. Grief, +7 authors H. Osiewacz
  • Published 2009
  • Biology, Medicine
  • PLoS ONE
  • In previous investigations an impact of cellular copper homeostasis on ageing of the ascomycete Podospora anserina has been demonstrated. Here we provide new data indicating that mitochondria play a major role in this process. Determination of copper in the cytosolic fraction using total reflection X-ray fluorescence spectroscopy analysis and eGfp reporter gene studies indicate an age-related increase of cytosolic copper levels. We show that components of the mitochondrial matrix (i.e. eGFP… CONTINUE READING
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