Age-Dependent Transcriptome and Proteome Following Transection of Neonatal Spinal Cord of Monodelphis domestica (South American Grey Short-Tailed Opossum)

@inproceedings{Saunders2014AgeDependentTA,
  title={Age-Dependent Transcriptome and Proteome Following Transection of Neonatal Spinal Cord of Monodelphis domestica (South American Grey Short-Tailed Opossum)},
  author={Norman R Saunders and Natassya M. Noor and Katarzyna Magdalena Dziegielewska and Benjamin J. Wheaton and Shane A Liddelow and David L. Steer and Carl Joakim Ek and Mark D Habgood and Matthew J. Wakefield and Helen Lindsay and Jessie S. Truettner and Robert D Miller and Alexander Ian Smith and W. Dalton Dietrich},
  booktitle={PloS one},
  year={2014}
}
This study describes a combined transcriptome and proteome analysis of Monodelphis domestica response to spinal cord injury at two different postnatal ages. Previously we showed that complete transection at postnatal day 7 (P7) is followed by profuse axon growth across the lesion with near-normal locomotion and swimming when adult. In contrast, at P28 there is no axon growth across the lesion, the animals exhibit weight-bearing locomotion, but cannot use hind limbs when swimming. Here we… CONTINUE READING