Age-Dependent Responsiveness of Human Female Cultured Bone Cells to Estrogenic Compounds

@article{Somjen2011AgeDependentRO,
  title={Age-Dependent Responsiveness of Human Female Cultured Bone Cells to Estrogenic Compounds},
  author={D. Somjen and S. Katzburg and A. Kaye and F. Kohen and G. Posner},
  journal={Endocrinology and Metabolic Syndrome},
  year={2011},
  volume={2011},
  pages={1-7}
}
Human cultured female osteoblasts (Obs) respond age-dependently to estradiol-17β (E2) and to phytoestrogens by increased DNA synthesis (DNA) and creatine kinase specific activity (CK). ERα mRNA expression is higher than ERβ mRNA in Obs. Pre-menopausal Ob (prOb) reveals higher expression of ERα than post-menopausal Ob (poOb), but similar intracellular and membranal E2 bindings. ERα mRNA is stimulated in prOb and inhibited in poOb by different estrogens. ERβ mRNA in prOb is stimulated by 2,3-bis… Expand

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Age-dependent responsiveness of human female bone cells to vitamin D analog and PTH

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