Age-Dependent Regulation of the Blood-Brain Barrier Influx/Efflux Equilibrium of Amyloid-β Peptide in a Mouse Model of Alzheimer's Disease (3xTg-AD).

@article{Do2016AgeDependentRO,
  title={Age-Dependent Regulation of the Blood-Brain Barrier Influx/Efflux Equilibrium of Amyloid-β Peptide in a Mouse Model of Alzheimer's Disease (3xTg-AD).},
  author={Tuan Minh Do and Agn{\`e}s Dodacki and Wael Alata and Fr{\'e}d{\'e}ric Calon and Sophie Nicolic and J. -M. Scherrmann and Robert Farinotti and Fanchon Bourasset},
  journal={Journal of Alzheimer's disease : JAD},
  year={2016},
  volume={49 2},
  pages={287-300}
}
The involvement of transporters located at the blood-brain barrier (BBB) has been suggested in the control of cerebral Aβ levels, and thereby in Alzheimer's disease (AD). However, little is known about the regulation of these transporters at the BBB in animal models of AD. In this study, we investigated the BBB expression of Aβ influx (Rage) and efflux (Abcb1-Abcg2-Abcg4-Lrp-1) transporters and cholesterol transporter (Abca1) in 3-18-month-old 3xTg-AD and control mice. The age-dependent effect… CONTINUE READING