Age-Dependent Enterocyte Invasion and Microcolony Formation by Salmonella

@inproceedings{Zhang2014AgeDependentEI,
  title={Age-Dependent Enterocyte Invasion and Microcolony Formation by Salmonella},
  author={Kaiyi Zhang and Aline Dupont and Natalia Torow and Fredrik Gohde and Sara Leschner and Stefan Lienenklaus and Siegfried Weiss and Melanie M Brinkmann and Mark K{\"u}hnel and Michael Hensel and Marcus Fulde and Mathias Hornef},
  booktitle={PLoS pathogens},
  year={2014}
}
The coordinated action of a variety of virulence factors allows Salmonella enterica to invade epithelial cells and penetrate the mucosal barrier. The influence of the age-dependent maturation of the mucosal barrier for microbial pathogenesis has not been investigated. Here, we analyzed Salmonella infection of neonate mice after oral administration. In contrast to the situation in adult animals, we observed spontaneous colonization, massive invasion of enteroabsorptive cells, intraepithelial… CONTINUE READING
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