Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm.

@article{Chen2016AgeAssociatedS1,
  title={Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm.},
  author={Hou-zao Chen and Fang Wang and P. P. Gao and Jian-Fei Pei and Yue Liu and Ting-Ting Xu and Xiaoqiang Tang and Wen-Yan Fu and Jie Lu and Yun-fei Yan and Xiao-man Wang and Lei Han and Zhu-qin Zhang and Ran Zhang and Ming-Hui Zou and De-Pei Liu},
  journal={Circulation research},
  year={2016},
  volume={119 10},
  pages={1076-1088}
}
RATIONALE Uncontrolled growth of abdominal aortic aneurysms (AAAs) is a life-threatening vascular disease without an effective pharmaceutical treatment. AAA incidence dramatically increases with advancing age in men. However, the molecular mechanisms by which aging predisposes individuals to AAAs remain unknown. OBJECTIVE In this study, we investigated the role of SIRT1 (Sirtuin 1), a class III histone deacetylase, in AAA formation and the underlying mechanisms linking vascular senescence and… CONTINUE READING

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