Age-Associated Metabolic and Morphologic Changes in Mitochondria of Individual Mouse and Hamster Oocytes

@inproceedings{SimsekDuran2013AgeAssociatedMA,
  title={Age-Associated Metabolic and Morphologic Changes in Mitochondria of Individual Mouse and Hamster Oocytes},
  author={Fatma Simsek-Duran and Fang Li and Wentia Ford and Robert James Swanson and Howard W Iii Jones and Frank J. Castora},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND In human oocytes, as in other mammalian ova, there is a significant variation in the pregnancy potential, with approximately 20% of oocyte-sperm meetings resulting in pregnancies. This frequency of successful fertilization decreases as the oocytes age. This low proportion of fruitful couplings appears to be influenced by changes in mitochondrial structure and function. In this study, we have examined mitochondrial biogenesis in both hamster (Mesocricetus auratus ) and mouse (Mus… CONTINUE READING
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Age - associated metabolic and morphologic changes in mitochondria of individual mouse and hamster Oocytes

  • W. Ford, R. J. Swanson, H. W. Jones, F. J. Castora
  • PLoS One
  • 2013

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