Age-Associated Increase in Cytokine Production During Systemic Inflammation-II: The Role of IL-1β in Age-Dependent IL-6 Upregulation in Adipose Tissue.

@article{Starr2015AgeAssociatedII,
  title={Age-Associated Increase in Cytokine Production During Systemic Inflammation-II: The Role of IL-1β in Age-Dependent IL-6 Upregulation in Adipose Tissue.},
  author={Marlene E. Starr and Mizuki Saito and Bernard Mark Evers and Hiroshi Saito},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2015},
  volume={70 12},
  pages={1508-15}
}
Expression of interleukin-6 (IL-6) upon acute inflammatory stress is significantly augmented by aging in adipose tissue, a major source of this cytokine. In the present study, we examined the mechanism of age-dependent IL-6 overproduction using visceral white adipose tissue from C57BL/6 mice. Upon treatment with lipopolysaccharide (LPS) in vitro, IL-6 was produced by adipose tissue explants, and secreted levels were significantly higher in cultures from aged (24 months) mice compared to young… CONTINUE READING
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