Age-Associated Decline in Human Femoral Neck Cortical and Trabecular Content of Insulin-Like Growth Factor I: Potential Implications for Age-Related (Type II) Osteoporotic Fracture Occurrence

@article{Boonen1997AgeAssociatedDI,
  title={Age-Associated Decline in Human Femoral Neck Cortical and Trabecular Content of Insulin-Like Growth Factor I: Potential Implications for Age-Related (Type II) Osteoporotic Fracture Occurrence},
  author={Steven Boonen and Jeroen Aerssens and Jan Dequeker and Patrick H F Nicholson and X.-G. Cheng and Geert Lowet and Geert Verbeke and R Bouillon},
  journal={Calcified Tissue International},
  year={1997},
  volume={61},
  pages={173-178}
}
Recent evidence suggests that regulatory peptides such as insulin-like growth factor-I (IGF-I) are released locally from bone during resorption, and may then act in a sequential manner to regulate the cellular events required for the coupling of bone formation to resorption. Among other factors, a decrease in bone-associated IGF-I levels could therefore result in remodeling imbalance and contribute to the gradual loss of bone that occurs with age. As the femoral neck region is of primary… CONTINUE READING

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