Age‐related increase of superoxide generation in the brains of mammals and birds

@article{Sasaki2008AgerelatedIO,
  title={Age‐related increase of superoxide generation in the brains of mammals and birds},
  author={Toru Sasaki and Keiko Unno and Shoichi Tahara and Atsuyoshi Shimada and Yoichi Chiba and Minoru Hoshino and Takao Kaneko},
  journal={Aging Cell},
  year={2008},
  volume={7}
}
Oxidative stress, an imbalance between endogenous levels of oxygen radicals and antioxidative defense, increases with aging. However, it is not clear which of these two factors is the more critical. To clarify the production of oxygen radicals increases with age, we examined oxygen radical‐dependent chemiluminescent signals in ex vivo brain slices using a novel photonic imaging method. The chemiluminescent intensity was significantly decreased by the membrane permeable superoxide dismutase (SOD… 
Age‐related increase of reactive oxygen generation in the brains of mammals and birds: Is reactive oxygen a signaling molecule to determine the aging process and life span?
TLDR
It is speculated that reactive oxygen might be a signaling molecule and its levels in tissue might determine the aging process and lifespan, and accelerating age‐related increases of reactive oxygen production are expected to be a potent strategy for anti‐aging interventions.
[Analysis of aging-related oxidative stress status in normal aging animals and development of anti-aging interventions].
  • Toru Sasaki
  • Chemistry, Medicine
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  • 2010
TLDR
It is speculated that reactive oxygen may be a kind of signal for aging and its levels in tissue may determine the aging process and life span and to decelerate the age-related increases of reactive oxygen production is expected as a potent strategy for anti-aging interventions.
Effects of aging and every-other-day feeding on the levels of oxygen radicals in rat brain slices
TLDR
The results indicated that age-dependent increases in superoxide production might be associated with enhanced oxidative stress in aged Fischer rat brains, but indicated that decreased superoxideProduction might not be a major causal factor in caloric and food restriction attenuated oxidative stress.
Age-Dependent Changes of Redox Ratio in Rat Brain Parts, Internal Organs and Blood Plasma
Aging of the body is accompanied by a gradual development of the oxidative stress. However, this process has different rates in various systems of the body; so, it seems interesting to compare the
Oxidative stress and the senescence acceleration in senescence-accelerated mouse P10 (SAMP10)
Abstract It has been hypothesized that oxidative stress, which is an imbalance between endogenous levels of oxygen radicals and antioxidant defense systems, is the main cause of aging.
Superoxide dismutase deficiency enhances superoxide levels in brain tissues during oxygenation and hypoxia‐reoxygenation
TLDR
The present study indicated that the major site of intracellular superoxide generation in the brain during oxygenation is the cytoplasm, whereas it is the mitochondria during reoxygenation.
Superoxide generation in different brain regions of rats during normoxia and hypoxia-reoxygenation
TLDR
The results suggest that superoxide generation is high in the hippocampus during normoxia and low in the white matter during normxia and hypoxia-reoxygenation brain correlates with the strength of Hypoxia influenced by oxygen delivery, and mitochondrion is the major sites of intracellular superoxidegeneration.
Elucidation of the mechanism of changes in the antioxidant function with the aging in the liver of the senescence-accelerated mouse P10 (SAMP10)
TLDR
The results suggest that some impairment in the regulation mechanism of FoxO‐1a phosphorylation is responsible for abnormal catalase expression and that a significant decrease in the level of catalases with aging decisively affects the metabolic balance of ROS.
Vitamin C depletion increases superoxide generation in brains of SMP30/GNL knockout mice.
TLDR
VC depletion specifically increased superoxide generation in a model of the living brain by using a real-time imaging system in which Lucigenin is the chemiluminescent probe for detecting superoxide in senescence marker protein-30/gluconolactonase knockout mice, which cannot synthesize VC in vivo.
Metabolic rate and oxygen radical levels increase but radical generation rate decreases with male age in Drosophila melanogaster sperm.
TLDR
Sperm from older males had higher mitochondrial ROS levels and a higher metabolic rate but produced ROS at a lower rate, which support the idea of a tissue-specific optimal rate of aerobic respiration balancing the production and removal of ROS, with aging causing a shift away from this optimum and leading to increased ROS accumulation.
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