Age‐Dependent Expression of Human Drug‐Metabolizing Enzymes

@inproceedings{Hines2012AgeDependentEO,
  title={Age‐Dependent Expression of Human Drug‐Metabolizing Enzymes},
  author={Ronald N Hines},
  year={2012}
}
Changes in hepatic drug-metabolizing enzyme expression during development are substantial and can affect the risk of adverse events in the fetus and child. In contrast, modest changes, if any, in the expression of these enzymes occur in the elderly, suggesting observed decreases in metabolic ability, which are more likely attributed to changes in physiological parameters. Increased knowledge of drub-metabolizing enzyme ontogeny, combined with knowledge regarding life-stage-dependent changes in… CONTINUE READING

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