Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes. The LADIS (Leukoaraiosis and Disability in the Elderly) Study.

@article{Basile2006AgeHA,
  title={Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes. The LADIS (Leukoaraiosis and Disability in the Elderly) Study.},
  author={Anna Maria Basile and Leonardo Pantoni and Giovanni Pracucci and Kjell Asplund and Hugues Chabriat and Timo Erkinjuntti and Franz Fazekas and Jose M. Ferro and Michael Hennerici and John T. O'Brien and Philip Scheltens and Marieke Christine Visser and Lars-Olof Wahlund and Gunhild Waldemar and Anders Wallin and Domenico Inzitari},
  journal={Cerebrovascular diseases},
  year={2006},
  volume={21 5-6},
  pages={315-22}
}
BACKGROUND Age-related white matter changes (ARWMC), seen on neuroimaging with high frequency in older people, are thought to be consequent to the effect of vascular risk factors and vascular diseases including hypertension and stroke. Among the proofs conventionally required for a factor to be considered a risk factor for a definite pathology, there is the demonstration of a trend in risk exposure related to disease severity. We sought whether such a trend existed in the association of… CONTINUE READING

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