Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes. The LADIS (Leukoaraiosis and Disability in the Elderly) Study.

@article{Basile2006AgeHA,
  title={Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes. The LADIS (Leukoaraiosis and Disability in the Elderly) Study.},
  author={Anna Maria Basile and Leonardo Pantoni and Giovanni Pracucci and Kjell Asplund and Hugues Chabriat and Timo Erkinjuntti and Franz Fazekas and Jos{\'e} M. Ferro and Michael Hennerici and John T. O'Brien and Philip Scheltens and Marieke Christine Visser and Lars-Olof Wahlund and Gunhild Waldemar and Anders Wallin and Domenico Inzitari},
  journal={Cerebrovascular diseases},
  year={2006},
  volume={21 5-6},
  pages={
          315-22
        }
}
BACKGROUND Age-related white matter changes (ARWMC), seen on neuroimaging with high frequency in older people, are thought to be consequent to the effect of vascular risk factors and vascular diseases including hypertension and stroke. Among the proofs conventionally required for a factor to be considered a risk factor for a definite pathology, there is the demonstration of a trend in risk exposure related to disease severity. We sought whether such a trend existed in the association of… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 96 CITATIONS, ESTIMATED 46% COVERAGE

Volume of white matter hyperintensities increases with blood pressure in patients with hypertension

  • The Journal of international medical research
  • 2019
VIEW 14 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Silent brain infarcts and leukoaraiosis in young adults with first-ever ischemic stroke.

  • Neurology
  • 2009
VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Sleep-related breathing disorders in acute lacunar stroke

  • Journal of Neurology
  • 2009
VIEW 2 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2007
2019

CITATION STATISTICS

  • 5 Highly Influenced Citations

  • Averaged 8 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 28 REFERENCES

Impact of age - related cerebral white matter changes on the transition to disability . The LADIS study : rationale , design and methodology

MP Lawton, EM Brody
  • Neuroepide - miology
  • 2005

Inci - dence , manifestations , and predictors of worsening white matter on serial cranial magnetic resonance imaging in the elderly : the Cardiovascular Health Study

L Pantoni, C Sarti, +3 authors D Inzitari
  • Stroke
  • 2005

, and cerebral white matter lesions : cardiovascular determinants of dementia study

T Jeerakathil, PA Wolf, +4 authors C DeCarli
  • Stroke
  • 2004

risk profi le predicts white matter hyperinten - sity volume : the Framingham Study

WT Longstreth, AM Arnold, +6 authors CD Furberg
  • 2004

Hypertension and cerebral white matter lesions in a prospective cohort study

F. E. de Leeuw, de Jan Groot, +4 authors Monique M.B. Breteler
  • 2002

Signifi - cance of white matter high intensity lesions as a predictor of stroke from arteriolosclerosis

D Inzitari, M Cadelo, ML Marranci, G Pracucci, L Pantoni
  • J Neurol Neurosurg Psychiatry
  • 2002

Atrial fi brillation

JI Weitz, J Byrne, +5 authors LM Taylor
  • N Engl J Med
  • 2001

Longitudinal study of blood pressure and white matter hyperintensities: the EVA MRI Cohort

C Levy, E Auffray, L Brunnereau, A Alperovitch, C Tzourio
  • Neurology
  • 2001