Age, anatomic site, and the replication and differentiation of adipocyte precursors.

@article{Kirkland1990AgeAS,
  title={Age, anatomic site, and the replication and differentiation of adipocyte precursors.},
  author={James l. Kirkland and Charles H. Hollenberg and Wanda Gillon},
  journal={The American journal of physiology},
  year={1990},
  volume={258 2 Pt 1},
  pages={C206-10}
}
The effects of donor age and anatomic site on cellular replication and differentiation were studied in adipocyte precursors cloned from epididymal and perirenal depots of young, middle-aged, and senescent rats. As animals aged from 3 to 29 mo, there was a progressive reduction in the proportion of cells capable of extensive replication in both depots. An inverse relation between clonal capacity for replication and differentiation was found. This relation was affected by donor site but not age… CONTINUE READING