Age, Alzheimer disease, and brain structure.

  title={Age, Alzheimer disease, and brain structure.},
  author={Cyrus A. Raji and Oscar L. Lopez and Lewis H. Kuller and Owen T. Carmichael and James T. Becker},
  volume={73 22},
BACKGROUND Lack of clear understanding remains on the overlapping atrophy patterns of aging and early Alzheimer disease (AD) pathology in gray matter (GM) of the brain in vivo. OBJECTIVE To evaluate the independent and overlapping patterns of GM atrophy in normal aging and AD. METHODS A total of 169 cognitively normal subjects and 33 persons with probable AD enrolled in the longitudinal Cardiovascular Health Study-Cognition Study underwent 3-dimensional volumetric MRI scans. Controls… CONTINUE READING

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