Agarose gel stiffness determines rate of DRG neurite extension in 3D cultures.

@article{Balgude2001AgaroseGS,
  title={Agarose gel stiffness determines rate of DRG neurite extension in 3D cultures.},
  author={A P Balgude and Xiaojun Yu and Andrzej Szymański and Ravi V. Bellamkonda},
  journal={Biomaterials},
  year={2001},
  volume={22 10},
  pages={1077-84}
}
The optimization of scaffold mechanical properties for neurite extension is critical for neural tissue engineering. Agarose hydrogels can be used to stimulate and maintain three-dimensional neurite extension from primary sensory ganglia in vitro. The present study explores the structure-function relationship between dorsal root ganglion (DRG) neurite extension and agarose gel mechanical properties. A range of agarose gels of differing concentrations were generated and the corresponding rate of… CONTINUE READING
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