Agalactosyl IgG: an aid to differential diagnosis in early synovitis.

  title={Agalactosyl IgG: an aid to differential diagnosis in early synovitis.},
  author={Adam Young and Nazira Sumar and K B Bodman and Sanjeev B Goyal and Hannah M Sinclair and Ivan M. Roitt and David Alan Isenberg},
  journal={Arthritis and rheumatism},
  volume={34 11},
Sixty consecutive patients presenting with early-onset synovitis were studied by measuring rheumatoid factor (RF) titers and the percentage of oligosaccharide chains attached to the C gamma 2 domain of IgG that lack galactose (GAL[0]). After 2 years of followup, 39 patients (65%) had developed rheumatoid arthritis (RA), and 21 had developed a variety of other inflammatory joint diseases. A combination of RF positivity and GAL(0) levels above the age-corrected mean gave a positive predictive… CONTINUE READING

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