Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans.

@article{Doonan2008AgainstTO,
  title={Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans.},
  author={Ryan Doonan and Joshua J. McElwee and Filip Matthijssens and Glenda A Walker and Koen Houthoofd and Patricia Back and Andrea Matscheski and Jacques R. Vanfleteren and David Gems},
  journal={Genes & development},
  year={2008},
  volume={22 23},
  pages={3236-41}
}
The superoxide radical (O(2)(-)) has long been considered a major cause of aging. O(2)(-) in cytosolic, extracellular, and mitochondrial pools is detoxified by dedicated superoxide dismutase (SOD) isoforms. We tested the impact of each SOD isoform in Caenorhabditis elegans by manipulating its five sod genes and saw no major effects on life span. sod genes are not required for daf-2 insulin/IGF-1 receptor mutant longevity. However, loss of the extracellular Cu/ZnSOD sod-4 enhances daf-2… CONTINUE READING

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