Aftereffects of high-intensity DC stimulation on the electromechanical performance of ventricular muscle.

@article{Kodama1994AftereffectsOH,
  title={Aftereffects of high-intensity DC stimulation on the electromechanical performance of ventricular muscle.},
  author={Itsuo Kodama and Nitaro Shibata and Ichiro Sakuma and Kazuyuki Mitsui and Masatoshi Iida and Ryoko Suzuki and Yasuhiro Fukui and Saichi Hosoda and Junji Toyama},
  journal={The American journal of physiology},
  year={1994},
  volume={267 1 Pt 2},
  pages={H248-58}
}
To clarify the mechanisms underlying cardiac dysfunction after electrical defibrillation, we investigated the effects of direct current field stimulation (10 ms, 1-80 V/cm) on isolated guinea pig papillary muscles. Shocks (S2) > 15 V/cm lowered the plateau height of the S2-induced action potential and inhibited its terminal repolarization. Subsequent responses to basic stimuli (S1, 1.0 Hz) for 1-3 min were characterized by a decrease in the maximum diastolic potential, a shortening of action… CONTINUE READING
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