• Biology
  • Published 2008

After a decade-long hiatus from science, Jane Skok returned to the lab to study the mechanism that allows each B cell to secrete antibodies that recognize only one target. Jane Skok: Choreography of allelic exclusion

@inproceedings{Skok2008AfterAD,
  title={After a decade-long hiatus from science, Jane Skok returned to the lab to study the mechanism that allows each B cell to secrete antibodies that recognize only one target. Jane Skok: Choreography of allelic exclusion},
  author={Jane Skok},
  year={2008}
}
Antibody diversity is generated during B cell development by the rearrangement of variable (V), diversity (D), and joining (J) segments of immunoglobulin (Ig) genes. Both alleles of each Ig locus can initiate rearrangement, but only one allele successfully rearranges. As soon as this occurs, the other allele is prevented from following suit. This mechanism, known as allelic exclusion, guarantees that each B cell produces antibodies specific for just one antigen. In her laboratory at New York… CONTINUE READING