# African trypanosomes and brain infection - the unsolved question.

```@article{Mogk2017AfricanTA,
title={African trypanosomes and brain infection - the unsolved question.},
author={Stefan Mogk and Christian M Bo\sselmann and Celestin Nzanzu Mudogo and Jasmin Stein and Hartwig Wolburg and Michael Duszenko},
journal={Biological reviews of the Cambridge Philosophical Society},
year={2017},
volume={92 3},
pages={1675-1687}
}```
African trypanosomes induce sleeping sickness. The parasites are transmitted during the blood meal of a tsetse fly and appear primarily in blood and lymph vessels, before they enter the central nervous system. During the latter stage, trypanosomes induce a deregulation of sleep-wake cycles and some additional neurological disorders. Historically, it was assumed that trypanosomes cross the blood-brain barrier and settle somewhere between the brain cells. The brain, however, is a strictly… CONTINUE READING

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The brain , however , is a strictly controlled and immune - privileged area that is completely surrounded by a dense barrier that covers the blood vessels : this is the blood - brain barrier .
The brain , however , is a strictly controlled and immune - privileged area that is completely surrounded by a dense barrier that covers the blood vessels : this is the blood - brain barrier .
The brain , however , is a strictly controlled and immune - privileged area that is completely surrounded by a dense barrier that covers the blood vessels : this is the blood - brain barrier .
The brain , however , is a strictly controlled and immune - privileged area that is completely surrounded by a dense barrier that covers the blood vessels : this is the blood - brain barrier .
Therefore , the parasite did not cross the blood - brain barrier , but the blood - CSF barrier , which is formed by the choroid plexus , i.e. the part of the ventricles where CSF is produced from blood .
Therefore , the parasite did not cross the blood - brain barrier , but the blood - CSF barrier , which is formed by the choroid plexus , i.e. the part of the ventricles where CSF is produced from blood .
Historically , it was assumed that trypanosomes cross the blood - brain barrier and settle somewhere between the brain cells .
Historically , it was assumed that trypanosomes cross the blood - brain barrier and settle somewhere between the brain cells .
Therefore , the parasite did not cross the blood - brain barrier , but the blood - CSF barrier , which is formed by the choroid plexus , i.e. the part of the ventricles where CSF is produced from blood .
Therefore , the parasite did not cross the blood - brain barrier , but the blood - CSF barrier , which is formed by the choroid plexus , i.e. the part of the ventricles where CSF is produced from blood .
Therefore , the parasite did not cross the blood - brain barrier , but the blood - CSF barrier , which is formed by the choroid plexus , i.e. the part of the ventricles where CSF is produced from blood .
Structure of choroid plexusAnatomic structure is physical part ofCerebral Ventricles
Therefore , the parasite did not cross the blood - brain barrier , but the blood - CSF barrier , which is formed by the choroid plexus , i.e. the part of the ventricles where CSF is produced from blood .
Therefore , the parasite did not cross the blood - brain barrier , but the blood - CSF barrier , which is formed by the choroid plexus , i.e. the part of the ventricles where CSF is produced from blood .