African swine fever virus IAP homologue inhibits caspase activation and promotes cell survival in mammalian cells.

@article{Nogal2001AfricanSF,
  title={African swine fever virus IAP homologue inhibits caspase activation and promotes cell survival in mammalian cells.},
  author={Mar{\'i}a L. Nogal and Gonzalo Gonz{\'a}lez de Buitrago and Cristina Rodr{\'i}guez and Beatriz Cubelos and Angel L. Carrascosa and Mar{\'i}a L. Salas and Yolanda Revilla},
  journal={Journal of virology},
  year={2001},
  volume={75 6},
  pages={
          2535-43
        }
}
African swine fever virus (ASFV) A224L is a member of the inhibitor of apoptosis protein (IAP) family. We have investigated the antiapoptotic function of the viral IAP both in stably transfected cells and in ASFV-infected cells. A224L was able to substantially inhibit caspase activity and cell death induced by treatment with tumor necrosis factor alpha and cycloheximide or staurosporine when overexpressed in Vero cells by gene transfection. We have also observed that ASFV infection induces… CONTINUE READING

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