African Origin of Modern Humans in East Asia: A Tale of 12,000 Y Chromosomes

@article{Ke2001AfricanOO,
  title={African Origin of Modern Humans in East Asia: A Tale of 12,000 Y Chromosomes},
  author={Yue-hai Ke and Bing Su and X. Song and Daru Lu and Liang-bi Chen and Heng Li and Chunjian Qi and Sangkot Marzuki and Ranjan Deka and Peter A. Underhill and Chunjie Xiao and Mark David Shriver and Jeffrey T. Lell and Douglas Wallace and R Spencer Wells and Mark Seielstad and Peter J. Oefner and D Zhu and J. Jin and W. Huang and Ranajit Chakraborty and Zugen Chen and L Jin},
  journal={Science},
  year={2001},
  volume={292},
  pages={1151 - 1153}
}
To test the hypotheses of modern human origin in East Asia, we sampled 12,127 male individuals from 163 populations and typed for three Y chromosome biallelic markers (YAP, M89, and M130). All the individuals carried a mutation at one of the three sites. These three mutations (YAP+, M89T, and M130T) coalesce to another mutation (M168T), which originated in Africa about 35,000 to 89,000 years ago. Therefore, the data do not support even a minimal in situ hominid contribution in the origin of… Expand

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